Esin B. Sözer
Research Assistant Professor
Old Dominion University
Frank Reidy Research Center for Bioelectrics
Laboratory of Multiscale Bioelectrical Interactions
I am interested in utilizing and understanding biophysical interactions of electric fields with multiscale biological systems ranging from pure lipid vesicles to cancer cells, and to the model organism C. elegans. To reach my research goals, I develop innovative, precise, and quantitative experimental methods and analysis tools, which aim to both increase our understanding and enable future technologies.
I especially enjoy connecting experiments to models. The experimental techniques rely heavily on confocal fluorescence microscopy for real-time simultaneous imaging of biological systems while being exposed to electrical stress, and both analytical and molecular modeling are utilized for our theoretical work. Below you can see an example where I connected confocal fluorescence microscopy measurements of molecular transport of fluorescent dye calcein into live cells exposed to a short electric field to the analytical calculations. Using an analytical model of transport, I showed an effect of low, but non-zero, membrane potential after electropermeabilization. This role of membrane potential has been largely neglected in models of electropermeabilization since the theory suggests a highly conductive membrane and this often is interpreted as it cannot carry any potential. Our results contradicted this long-held notion repeated many times in the literature. I presented these results at BioEM 2016, where I received the first Arthur Pilla Young Scientist award. (https://arthurpilla.com/2017/03/14/meet-the-very-first-arthur-pilla-young-scientist-award-recipient/)
For active projects I am involved in visit "Projects" and for more examples of my contributions visit "Bio" page.